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quinupristin/dalfopristin will enhance the stage or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Drugs that need prior authorization. This restriction requires that particular clinical criteria be achieved prior to the approval with the prescription.
Benzodiazepines may possibly improve hazards of abuse, misuse, and dependancy, which may lead to overdose or death
Cell phone 999 or go to A&E if: You or some other person has taken benzodiazepines and has indications like:
Paradoxical reactions may well manifest like hallucinations, intense behavior, and psychoses; dinscontinue use if reactions occur
aprepitant will boost the stage or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Lencapavir (a average CYP3A4 inhibitor) could maximize CYP3A4 substrates initiated within nine months soon after last SC dose of lenacapavir, which may raise prospective possibility of adverse reactions of CYP3A4 substrates.
It truly is an offence to generate a vehicle In the event your capacity to push safely is afflicted. It truly is your accountability to decide if It truly is Secure to drive. In case you are in any question, never drive.
stiripentol will lessen the extent or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Carefully. Look at decreasing the dose of CYP2C19 substrates, if adverse reactions are expert when administered concomitantly with stiripentol.
Naloxone will likely not reverse a benzodiazepine-only overdose but it is going to do no harm in case you administer it when it’s not essential.
Occasionally, benzodiazepine users have formulated a protracted withdrawal syndrome with withdrawal indicators Long lasting months to in excess of 12 months
Check Carefully (1)larotrectinib will enhance the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Sturdy or reasonable CYP3A4 inhibitors may perhaps minimize level of diazepam elimination, thereby escalating adverse reactions to diazepam.
Stay away from or substitute One more drug for these drugs when achievable. Appraise for loss of therapeutic effect if medication need to be coadministered.
Active metabolites: N-desmethyldiazepam and temazepam, that happen to website be both of those further more metabolized to oxazepam; mainly removed by glucuronidation